- Hubbed in Pittsburgh, All American Aviation Company began serving the Ohio River valley in 1939.
- Ten years later, the company changed its name to All American Airways, switching from airmail to passenger service.
- In 1953, All American Airways changed its name to Allegheny Airlines.
- In the following two decades, Allegheny Airlines expanded progressively, adding the Douglas DC-9 jet to its fleet in 1966 and acquiring Lake Central Airlines in 1968 and Mohawk Airlines, in 1972.
- In 1979, Allegheny Airlines changed its name to USAir, later acquiring San Diego-based PSA (Pacific Southwest Airlines) (1987) and Winston-Salem, NC-based Piedmont Airlines (1988).
- In late November, 1984, USAir received its first Boeing 737, being the launch customer for the 737-300.
- In 1989, USAir was one of world's largest airlines, operating over 5,000 daily flights.
- During the early 1990s, USAir introduced flights to London, Paris and Frankfurt, accepting a large investment from British Airways that laid the foundation for one of the first transatlantic airline alliances.
- In 1996, after the alliance with British Airways ended in a court battle, USAir rebranded itself to US Airways.
- In late May, 2000, US Airways announced plans to be taken over by UAL Corp., the parent company of United Airlines, for no less than $4.3 billion, but negotiations stalled and the offer was withdrawn in late July, 2001, UAL paying $50 million to US Airways for this.
- On the 4th of May, 2004, US Airways became the 15th member of the Star Alliance.
- US Airways Group and America West Holdings were merged in mid-May, 2005, and the resulting airline retained the US Airways name.
- Since the merger, the airline continued its growth, but customer satisfaction remained really low, with US Airways being the leader in service complaints with 4.4 complaints per 100,000 customers (2007).
- Despite low customer satisfaction, US Airways was the number one ontime airline in 2008 among the big six hub and spoke carriers, maintaining its position during 2009, too.
- As of late 2009, US Airways (together with US Airways Express) operates over 3,100 daily flights to 200 destinations in 30 countries from its hubs in Phoenix, Charlotte and Philadelphia, .
- US Airways and US Air were involved in just a few deadly incidents, the worst (and also latest) of them occurring in early September, 1004, when a Boeing 737 crashed while maneuvering to land at Pittsburgh International Airport, killing all 132 people on board.